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Cold Sores - Effective Natural Treatment

Updated: Jun 5, 2020

If you've ever had a cold sore before, you know that familiar "tingle" sensation and burning or itching that appears before the cold sore even shows up. Cold Sores are a product of the herpes virus, usually herpes simplex virus type 1, and often goes by HSV for short. Once you have this virus, it is never actually eliminated from your body, it lives in your nervous system waiting patiently for your immune system to be weakened by stress or illness and then the virus can re-emerge and cause the tell-tale blisters which scab over as they heal. It is very contagious and easily spreads by contact. If you could have a cold sore it's important to not kiss, share food or utensils with others. Most susceptible to HSV infections are newborn babies, so please don't kiss a newborn without absolute certainty that a cold sore is not in the works.

Many rely on medications such as valacyclovir (Valtrex) and famciclovir (Famvir) orally to help eliminate the cold sore, but these antiviral medications have to be taken within 48 hrs of feeling the tingles (prodromal, or initial symptoms) and no later than actual appearance of the blisters, otherwise they aren't helpful (1). They also only reduce cold sore duration by about 1 day (2). Hardly a win for the most common adverse reactions of nausea, headache, vomiting, abdominal pain and fatigue that can come along with the medications (3). #nothanks

So what do you do about it?

Many over-the-counter treatments are just as effective as the medications and do not carry the side effects. I keep these items at home and on hand because starting them ASAP gives the best opportunity to prevent the cold sore from erupting entirely.

1. Lysine is am amino acid which helps inhibit HSV replication. Dosages of 3-5 gm per day orally are most helpful and can be used topically as well (4). I really like Super Lysine Plus ointment, when I use this the cold sore doesn't even have a chance to erupt! Always use a clean Q-tip to apply to prevent cross contamination with the bottle.

2. Herbs: Lemon Balm (5), Licorice root (6), St. John's Wort and Echinacea are all excellent choices for helping fight the virus and support immune system strength. Lemon balm grows all over my neighborhood and makes a delicious tea. While I sip the tea I'll usually soak the affected spot on the lip or dab a little on with a clean cotton ball or Q-tip throughout the day. #nature, #herbalmedicine

3. Nutrients: B12 injections can support the nerves where the virus lives and is replicating, helping to prevent and eliminate any residual sensitivity and pain. Vitamin C orally at 3000-5000 mg per day can also support the immune system as well as increasing vitamin D for a short period of time. Zinc in dosages of 30-60 mg per day for adults (in divided doses, with meals) can also help support the immune system and inhibit HSV viral replication and improve skin healing after the infection (4).

H2PLX contains many of these herbs and nutrients plus vitamin A and selenium which support immune function as well.




  4. Prousky, J. (2012) Textbook of Integrative Clinical Nutrition. CCNM Press Inc. p.246-249


  6. Hudson, T. (2008). Women’s Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness. McGraw-Hill Publishing. New York, NY p. 99-108


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