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When Chronic Stress Starts Affecting Your Physical Health

Updated: 5 days ago

stressed gentleman

Most people think of stress as purely emotional or psychological. But chronic stress can affect far more than mood alone. Over time, stress can begin to influence digestion, sleep, immune function, hormone balance, blood sugar regulation, inflammation, and energy levels.

In today's world, stress is very different than what we evolved to handle. Today's stressors are not tigers, bears and staying alive for most people. The lifestyle of constant connection through phones, emails, text messages, drowning in responsibilities at work and at home, upkeeping a desired appearance to others, the threat of world war, political uncertainty, loans and debt demands as well as the stress of upkeeping our own health is a recipe for disaster long term. Most people are living this 24/7, with no break in sight.


Many patients are surprised to learn how often symptoms like bloating, fatigue, brain fog, insomnia, headaches, skin issues, anxiety, or digestive problems may overlap with chronic nervous system dysregulation.


From a naturopathic perspective, emotional health and physical health are deeply interconnected. The body functions best when it feels safe, nourished, rested, and supported. When stress becomes chronic, the body may stay stuck in a prolonged “fight-or-flight” state that can gradually disrupt normal physiology.


mountain and lake in fog
Serene view of mountain and lake

Signs Stress May Be Affecting Your Health

Stress affects everyone differently. Some people primarily notice emotional symptoms, while others experience more physical manifestations.


Common signs of chronic stress or nervous system dysregulation may include:

  • Anxiety or irritability

  • Difficulty sleeping or staying asleep

  • Fatigue or burnout

  • Brain fog or poor concentration

  • Digestive symptoms such as bloating, IBS, constipation, or diarrhea

  • Increased inflammation or pain

  • Frequent illness or lowered immune resilience

  • Hormonal symptoms

  • Blood sugar instability or cravings

  • Feeling “wired but tired”



The Stress Response and the Body

When the body perceives stress, it activates the sympathetic nervous system and releases stress hormones such as cortisol and adrenaline. This response is designed to help us survive short-term danger. The problem is that modern stress is often ongoing.

Chronic psychological stress with poor sleep, overwork, inflammation, blood sugar instability, infections, relationship stress, trauma, or even excessive exercise can all contribute to prolonged nervous system activation. So can just watching the news in today's world!


Over time, this may affect:

  • Digestion and gut motility

  • Immune function

  • Hormone balance

  • Blood sugar regulation

  • Inflammatory pathways

  • Mood and emotional resilience

  • Sleep quality and circadian rhythm


Research continues to uncover how strongly the gut, immune system, nervous system, hormones, and microbiome communicate with one another.


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The Gut-Brain Connection

The digestive system and nervous system are closely linked through what is often called the “gut-brain axis.” Stress is well known to influence digestion, and digestive dysfunction can also influence the microbiome, mood and nervous system regulation.

petri dish with bacteria

Some patients notice that periods of high stress worsen symptoms such as:

  • Acid reflux

  • Nausea

  • IBS symptoms

  • Bloating

  • Appetite changes

  • Loose stools or constipation


In some cases, chronic stress is a key contributor to intestinal inflammation, or intestinal permeability (“leaky gut”). This can lead to increased food sensitivities, intolerances and chronic digestive symptoms as well as increased risk of autoimmune disease. Research suggests chronic stress may contribute to the development or worsening of autoimmune diseases.


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Functional Testing Sometimes Used in Chronic Stress Patterns

A thorough medical evaluation is extremely important for ruling out serious disease. However, standard testing may not always evaluate deeper patterns involving digestion, inflammation, hormones, nutrient status, or stress physiology. That's where functional lab testing truly shines.


microscope


Depending on symptoms and history, a naturopathic evaluation may sometimes include:


  • Cortisol rhythm or adrenal function testing

  • Comprehensive thyroid evaluation

  • Nutritional deficiency assessment

  • Blood sugar and metabolic evaluation

  • Gut health and microbiome testing

  • Inflammatory markers

  • Sleep and circadian rhythm assessment


The goal is not just to label symptoms or diagnose disease, but to also better understand why the body may be struggling and then using that information to change the environment and terrain so the body can recover appropriately.








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Lifestyle Factors That Support Nervous System Regulation

Healing does not usually come from one supplement or one perfect routine. More often, improvement comes from gradually creating conditions that help the nervous system feel safer and more regulated over time.


healthy bowl of food
  • Stabilizing blood sugar with adequate protein and balanced meals

  • Reducing highly processed foods

  • Supporting nutrient intake

  • Addressing digestive dysfunction where appropriate

  • Regular eating times and consistency


Sleep Support

  • Improving sleep consistency and circadian rhythm

  • Reducing overstimulation late in the evening

  • Supporting healthy cortisol and melatonin rhythm

exercise

Gentle Movement

  • Walking

  • Stretching

  • Yoga

  • Moderate exercise appropriate to energy levels


Nervous System Support

  • Breathing exercises

  • Meditation or mindfulness practices

  • Trauma-informed therapy or somatic therapies

  • Setting healthier boundaries and realistic expectations with family, friends and work (this is the biggest one!)


Other Therapies

Depending on the individual, additional therapies may include:

massage

Treatment should always be individualized based on symptoms, history, medications, and overall health status. That's why we always start with a comprehensive physical exam and set of standard labs to screen for problems as well as nutrient deficiencies. Then we layer in any functional lab tests depending on the needs of the individual.


A More Comprehensive Approach to Stress and Health

Many patients seek naturopathic care because they feel exhausted, overwhelmed, inflamed, or chronically unwell despite being told their labs are “normal.”

woman breathing deeply

In many cases, there may not be one single cause. Instead, there may be a combination of stress physiology, poor sleep, inflammation, digestive dysfunction, nutrient depletion, hormonal imbalance, or nervous system dysregulation contributing to symptoms.


Addressing these patterns often requires looking at the body as an interconnected system rather than focusing on symptoms in isolation.


Ready to Explore a More Comprehensive Evaluation?

At Pacific Clinic of Natural Medicine, we take an individualized approach to stress-related health concerns, digestive dysfunction, hormone balance, inflammation, and nervous system regulation. We see stress affecting our patients' health all the time and have a comprehensive and reliable way to help.



We offer a complimentary 15-minute consultation for individuals interested in learning whether our approach may be a good fit for their health concerns.



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Schedule a 15-minute complimentary consultation

References

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  2. Chrousos GP. Stress and disorders of the stress system. Nature Reviews Endocrinology. 2009;5(7):374–381.

  3. Yaribeygi H, Panahi Y, Sahraei H, Johnston TP, Sahebkar A. The impact of stress on body function: A review. EXCLI Journal. 2017;16:1057–1072.

  4. Dhabhar FS. Effects of stress on immune function: the good, the bad, and the beautiful. Immunologic Research. 2014;58(2-3):193–210.

  5. Cryan JF, O’Riordan KJ, Cowan CSM, et al. The microbiota-gut-brain axis. Physiological Reviews. 2019;99(4):1877–2013.

  6. Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology. 2015;28(2):203–209.

  7. Mayer EA, Knight R, Mazmanian SK, Cryan JF, Tillisch K. Gut microbes and the brain: paradigm shift in neuroscience. Journal of Neuroscience. 2014;34(46):15490–15496.

  8. Moloney RD, Johnson AC, O’Mahony SM, Dinan TG, Greenwood-Van Meerveld B, Cryan JF. Stress and the microbiota-gut-brain axis in visceral pain. Molecular Psychiatry. 2016;21(7):968–974.

  9. Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiological Reviews. 2011;91(1):151–175.

  10. Sturgeon JA, Zautra AJ. Psychological resilience, pain catastrophizing, and positive emotions: perspectives on comprehensive modeling of individual pain adaptation. Current Pain and Headache Reports. 2013;17(3):317.

  11. Walker LS, Caplan-Dover A, Rasquin A. Rome III diagnostic questionnaire for the pediatric functional GI disorders. Journal of Pediatric Gastroenterology and Nutrition. 2006;43(5):593–600.

  12. Charmandari E, Tsigos C, Chrousos G. Endocrinology of the stress response. Annual Review of Physiology. 2005;67:259–284.

  13. Irwin MR, Opp MR. Sleep health: reciprocal regulation of sleep and innate immunity. Neuropsychopharmacology. 2017;42(1):129–155.

  14. Cohen S, Janicki-Deverts D, Miller GE. Psychological stress and disease. JAMA. 2007;298(14):1685–1687.

  15. Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological Bulletin. 2004;130(4):601–630.



About Pacific Clinic of Natural Medicine

Pacific Clinic of Natural Medicine is a naturopathic and functional medicine clinic in Portland, Oregon, serving patients in-person and virtually throughout Oregon and Washington, with functional wellness consulting available nationwide. Our physicians are licensed naturopathic doctors — the original root-cause practitioners — specializing in hormones, gut health, nutrient status, thyroid, autoimmune conditions, chronic fatigue, and more.


If you've been told your labs are normal but still don't feel well, we can help. We offer comprehensive functional lab testing, direct lab ordering without an appointment, and complimentary consultations to help you figure out where to start.


📍 511 SW 10th Avenue, Suite 707, Portland, OR 97205 | 📞 503-894-8977 | pacificnaturalmedicine.com



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